GPCR interacting proteins (GIPs) in the nervous system: Roles in physiology and pathologies

Annu Rev Pharmacol Toxicol. 2010;50:89-109. doi: 10.1146/annurev.pharmtox.010909.105705.


G protein-coupled receptors (GPCRs) are key transmembrane recognition molecules for regulatory signals such as light, odors, taste hormones, and neurotransmitters. In addition to activating guanine nucleotide binding proteins (G proteins), GPCRs associate with a variety of GPCR-interacting proteins (GIPs). GIPs contain structural interacting domains that allow the formation of large functional complexes involved in G protein-dependent and -independent signaling. At the cellular level, other functions of GIPs include targeting of GPCRs to subcellular compartments and their trafficking to and from the plasma membrane. Recently, roles of GPCR-GIP interactions in central nervous system physiology and pathologies have been revealed. Here, we highlight the role of GIPs in some important neurological and psychiatric disorders, as well as their potential for the future development of therapeutic drugs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antidepressive Agents / pharmacology
  • Anxiety / etiology
  • Brain / physiology*
  • Carrier Proteins / physiology*
  • Epilepsy / etiology
  • Fragile X Syndrome / etiology
  • Homer Scaffolding Proteins
  • Humans
  • Mood Disorders / drug therapy
  • Neuronal Plasticity
  • Nuclear Proteins / physiology
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate / physiology
  • Receptors, Serotonin / physiology
  • Schizophrenia / etiology
  • Synaptic Transmission


  • Antidepressive Agents
  • Carrier Proteins
  • G-protein-coupled receptor interacting protein GIP, human
  • Homer Scaffolding Proteins
  • Nuclear Proteins
  • PICk1 protein, human
  • Receptor, Metabotropic Glutamate 5
  • Receptors, Metabotropic Glutamate
  • Receptors, Serotonin
  • metabotropic glutamate receptor 7
  • metabotropic glutamate receptor type 1