Clindamycin-resistant group B Streptococcus and failure of intrapartum prophylaxis to prevent early-onset disease

J Pediatr. 2010 Mar;156(3):501-3. doi: 10.1016/j.jpeds.2009.10.048. Epub 2010 Jan 13.


Guidelines recommend intrapartum antibiotic prophylaxis (IAP) for parturient women who have a screen positive for group B Streptococcus (GBS). Clindamycin should be used for IAP only if the maternal GBS isolate is susceptible. We report a case of clindamycin-resistant GBS disease in a newborn infant whose mother received clindamycin IAP, and we review clindamycin susceptibility testing.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotic Prophylaxis*
  • Clindamycin / therapeutic use*
  • Drug Resistance, Bacterial
  • Female
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical / prevention & control*
  • Male
  • Microbial Sensitivity Tests
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy
  • Streptococcal Infections / drug therapy
  • Streptococcal Infections / prevention & control*
  • Streptococcus agalactiae* / drug effects


  • Clindamycin