Defending the genome in tudor style

Dev Cell. 2009 Dec;17(6):745-6. doi: 10.1016/j.devcel.2009.11.007.


Repression of transposable elements is crucial for the survival of germ cells. In this issue of Developmental Cell, Shoji et al. provide evidence that a Tudor domain protein TDRD9 partners with MIWI2 to specifically silence LINE-1 transposons in the fetal germline of male mice.

Publication types

  • Comment

MeSH terms

  • Animals
  • Genome*
  • Male
  • Mice
  • RNA, Small Interfering / metabolism
  • Retroelements*
  • Ribonucleoproteins, Small Nuclear / chemistry
  • Ribonucleoproteins, Small Nuclear / metabolism*


  • RNA, Small Interfering
  • Retroelements
  • Ribonucleoproteins, Small Nuclear