TTC3 ubiquitination terminates Akt-ivation

Dev Cell. 2009 Dec;17(6):752-4. doi: 10.1016/j.devcel.2009.12.003.


In this issue of Developmental Cell, Suizu et al. (2009) describe a new mechanism for posttranslational regulation of the Akt serine/threonine protein kinase involving ubiquitination. They show that the E3 ubiquitin ligase TTC3 modifies phosphorylated and activated Akt and thereby promotes its degradation by the proteasome in the nucleus.

Publication types

  • Comment

MeSH terms

  • Cell Nucleus / metabolism
  • Humans
  • Proteasome Endopeptidase Complex / metabolism
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Ubiquitin-Protein Ligases / metabolism*
  • Ubiquitination


  • TTC3 protein, human
  • Ubiquitin-Protein Ligases
  • Proto-Oncogene Proteins c-akt
  • Proteasome Endopeptidase Complex