FUS/TLS genetic variability in sporadic frontotemporal lobar degeneration

J Alzheimers Dis. 2010;19(4):1317-22. doi: 10.3233/JAD-2010-1328.


Two hundred and fifty one Italian patients with sporadic frontotemporal lobar degeneration (FTLD) and 259 age-matched controls were tested for association with the tagging single nucleotide polymorphisms (SNPs) rs741810 and rs1052352 in the fused in sarcoma/translated in liposarcoma gene (FUS/TLS). Only patients negative for GRN mutations were included. Considering each SNP alone, no differences in either allelic or genotypic frequencies between patients and controls were found (P > 0.05), even stratifying according to gender or the presence of concomitant motor neuron disease. Haplotype analysis failed to detect haplotypes associated with FTLD. According to these results, FUS/TLS is not a susceptibility factor for the development of sporadic FTLD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Frontotemporal Lobar Degeneration / genetics*
  • Genetic Variation / genetics*
  • Humans
  • Male
  • RNA-Binding Protein FUS / genetics*
  • Risk Factors


  • RNA-Binding Protein FUS