Molecular mediators of angiogenesis

J Burn Care Res. 2010 Jan-Feb;31(1):158-75. doi: 10.1097/BCR.0b013e3181c7ed82.


Angiogenesis, or the formation of new blood vessels from the preexisting vasculature, is a key component in numerous physiologic and pathologic responses and has broad impact in many medical and surgical specialties. In this review, we discuss the key cellular steps that lead to the neovascularization of tissues and highlight the main molecular mechanisms and mediators in this process. We include discussions on proteolytic enzymes, cell-matrix interactions, and pertinent cell signaling pathways and end with a survey of the mechanisms that lead to the stabilization and maturation of neovasculatures.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Endothelium, Vascular / physiology
  • Extracellular Matrix / physiology
  • Humans
  • Intercellular Signaling Peptides and Proteins / physiology*
  • Matrix Metalloproteinases / physiology
  • Neovascularization, Physiologic / physiology*
  • Signal Transduction


  • Intercellular Signaling Peptides and Proteins
  • Matrix Metalloproteinases