Real-time monitoring of drug release

Chem Commun (Camb). 2010 Jan 28;46(4):553-5. doi: 10.1039/b919329d. Epub 2009 Dec 10.

Abstract

A new prodrug system, assembled using a distinctive coumarin linker, was demonstrated to report real-time activation and drug release in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Alkylating / administration & dosage*
  • Antineoplastic Agents, Alkylating / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Coumarins / chemical synthesis
  • Coumarins / chemistry*
  • Drug Delivery Systems*
  • Humans
  • Melphalan / administration & dosage*
  • Melphalan / pharmacology
  • Molecular Structure
  • Prodrugs / chemical synthesis
  • Prodrugs / chemistry*

Substances

  • Antineoplastic Agents, Alkylating
  • Coumarins
  • Prodrugs
  • coumarin
  • Melphalan