Pregnancy after prophylactic total gastrectomy

Fam Cancer. 2010 Sep;9(3):331-4. doi: 10.1007/s10689-009-9316-y.


Hereditary diffuse gastric cancer is an autosomal dominant inherited cancer predisposition syndrome characterized by susceptibility to diffuse gastric and lobular breast cancers. Since current screening options for diffuse gastric cancer are ineffective, prophylactic total gastrectomy (PTG) is a recommended option for unaffected germline CDH1 mutation carriers. It is unknown whether pregnancy after surgery is possible or advisable due to potential maternal nutritional deficiencies. In this report we describe the pregnancy outcomes in three CDH1 mutation positive women after PTG and in a CDH1 mutation negative woman after total gastrectomy for early gastric cancer.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, CD
  • Cadherins / genetics
  • Female
  • Gastrectomy / adverse effects*
  • Genetic Predisposition to Disease
  • Humans
  • Pregnancy
  • Pregnancy Outcome*
  • Stomach Neoplasms / genetics
  • Stomach Neoplasms / prevention & control*
  • Young Adult


  • Antigens, CD
  • CDH1 protein, human
  • Cadherins