Neural correlates of movement generation in the 'at-risk mental state'

Acta Psychiatr Scand. 2010 Oct;122(4):295-301. doi: 10.1111/j.1600-0447.2009.01524.x. Epub 2010 Jan 7.


Objective: People with 'prodromal' symptoms have a very high risk of developing psychosis. We examined the neurocognitive basis of this vulnerability by using functional MRI to study subjects with an at-risk mental state (ARMS) while they performed a random movement generation task.

Method: Cross-sectional comparison of individuals with an ARMS (n = 17), patients with first episode schizophreniform psychosis (n = 10) and healthy volunteers (n = 15). Subjects were studied using functional MRI while they performed a random movement generation paradigm.

Results: During random movement generation, the ARMS group showed less activation in the left inferior parietal cortex than controls, but greater activation than in the first episode group.

Conclusion: The ARMS is associated with abnormalities of regional brain function that are qualitatively similar to those in patients who have recently presented with psychosis but less severe.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antipsychotic Agents / therapeutic use
  • Causality
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / pathology*
  • Cerebral Cortex / physiopathology
  • Cross-Sectional Studies
  • Disease Susceptibility
  • Humans
  • Magnetic Resonance Imaging
  • Mental Health
  • Motor Activity
  • Psychotic Disorders* / diagnosis
  • Psychotic Disorders* / epidemiology
  • Psychotic Disorders* / physiopathology
  • Psychotic Disorders* / therapy
  • Schizophrenia / diagnosis
  • Schizophrenia / epidemiology
  • Schizophrenia / physiopathology
  • Schizophrenia / therapy
  • Task Performance and Analysis


  • Antipsychotic Agents