Shifting players and paradigms in cell-specific transcription

Mol Cell. 2009 Dec 25;36(6):924-31. doi: 10.1016/j.molcel.2009.12.011.


Historically, developmental-stage- and tissue-specific patterns of gene expression were assumed to be determined primarily by DNA regulatory sequences and their associated activators, while the general transcription machinery including core promoter recognition complexes, coactivators, and chromatin modifiers was held to be invariant. New evidence suggests that significant changes in these general transcription factors including TFIID, BAF, and Mediator may facilitate global changes in cell-type-specific transcription.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Developmental*
  • Mediator Complex / genetics
  • Mediator Complex / metabolism
  • Models, Molecular
  • Promoter Regions, Genetic
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • TATA Box Binding Protein-Like Proteins / genetics
  • TATA Box Binding Protein-Like Proteins / metabolism
  • Tissue Distribution
  • Transcription Factor TFIID / genetics
  • Transcription Factor TFIID / metabolism
  • Transcription, Genetic*


  • Mediator Complex
  • Protein Isoforms
  • TATA Box Binding Protein-Like Proteins
  • Transcription Factor TFIID