Effect of nut consumption on oxidative stress and the endothelial function in metabolic syndrome

Clin Nutr. 2010 Jun;29(3):373-80. doi: 10.1016/j.clnu.2009.12.008. Epub 2010 Jan 12.


Background & aims: Oxidative stress has a key role in atherosclerosis, cancer and other chronic diseases. Some bioactive compounds in nuts have been implicated in antioxidant activities.

Objective: We assessed how nut consumption affected several markers of oxidation and endothelial function (EF) in metabolic syndrome (MetS) patients.

Patients and methods: A randomized, controlled, parallel feeding trial was conducted on 50 MetS adults who were recommended a healthy diet supplemented or not with 30 g of mixed nuts (Nut and Control groups, respectively) every day for 12 weeks. The plasma antioxidant capacity (AC), oxidized LDL (oxLDL), conjugated diene (CD) formation, urine 8-isoprostanes, DNA damage assessed by yield of urine 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG), and EF assessed by peripheral artery tonometry (PAT) and biochemical markers, were measured at baseline and the end of the intervention.

Results: No significant differences in changes between groups were observed in AC, oxLDL, CD, 8-isoprostanes or EF during the intervention, whereas the reduction in DNA damage was significant in the Nut group compared to Control group (P < 0.001).

Conclusion: Nut consumption has no deleterious effect on lipid oxidation. The decrease in DNA damage observed in this study could contribute to explain the beneficial effects of regular nut consumption on some MetS features and several chronic diseases.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine
  • Adolescent
  • Adult
  • Aged
  • Antioxidants / metabolism
  • Arteries / physiopathology
  • Biomarkers / blood
  • Biomarkers / urine
  • DNA Damage
  • Deoxyguanosine / analogs & derivatives
  • Deoxyguanosine / urine
  • Diet
  • Endothelium, Vascular / physiopathology*
  • Fatty Acids, Unsaturated / blood
  • Fatty Acids, Unsaturated / chemistry
  • Humans
  • Isoprostanes / urine
  • Lipoproteins, LDL / blood
  • Male
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / diet therapy*
  • Metabolic Syndrome / physiopathology*
  • Metabolic Syndrome / urine
  • Middle Aged
  • Nuts* / adverse effects
  • Oxidative Stress / physiology*
  • Vascular Resistance
  • Young Adult


  • Antioxidants
  • Biomarkers
  • Fatty Acids, Unsaturated
  • Isoprostanes
  • Lipoproteins, LDL
  • oxidized low density lipoprotein
  • 8-Hydroxy-2'-Deoxyguanosine
  • Deoxyguanosine

Associated data

  • ISRCTN/ISRCTN36468613