Could uric acid be a modifiable risk factor in subjects with pulmonary hypertension?

Med Hypotheses. 2010 Jun;74(6):1069-74. doi: 10.1016/j.mehy.2009.12.023. Epub 2010 Jan 12.


A high serum uric acid is common in subjects with pulmonary hypertension. The increase in serum uric acid may be a consequence of the local tissue ischemia and/or hypoxia, and it may also result from other factors independent of ischemia or hypoxia that occur in various forms of pulmonary hypertension. While classically viewed as a secondary phenomenon, recent studies suggest that hyperuricemia may also have a role in mediating the local vasoconstriction and vascular remodeling in the pulmonary vasculature. If uric acid does have a contributory role in pulmonary hypertension, we may see an increasing prevalence of pulmonary hypertension as hyperuricemia is common in subjects with obesity and metabolic syndrome. We propose studies to investigate the role of uric acid in pulmonary hypertension and to determine if lowering serum uric acid may have clinical benefit in this condition.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Humans
  • Hypertension, Pulmonary / blood*
  • Hypertension, Pulmonary / etiology*
  • Hypertension, Pulmonary / therapy
  • Hyperuricemia / blood
  • Hyperuricemia / complications
  • Hypoxia / complications
  • Models, Biological
  • Oxidative Stress
  • Risk Factors
  • Uric Acid / blood*
  • Vasoconstriction / physiology


  • Uric Acid