Genome-based approaches to vaccine development

J Mol Med (Berl). 2010 Feb;88(2):143-7. doi: 10.1007/s00109-009-0574-9.


The hundreds of bacterial genome sequences available together with advances in bioinformatics and the development of new experimental proteomic tools are revolutionizing the vaccinology field. The merge of stringent in silico criteria and different experimental approaches is allowing a more targeted strategy to obtain a restricted and prioritized list of potential antigens for testing in immunogenicity assays, reducing the time and the cost of novel protein vaccine formulations.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, Bacterial / genetics*
  • Antigens, Bacterial / immunology
  • Bacterial Vaccines / genetics*
  • Bacterial Vaccines / immunology
  • Computational Biology
  • Drug Design
  • Genome, Bacterial / genetics*
  • Genomics / methods*
  • Humans


  • Antigens, Bacterial
  • Bacterial Vaccines