Wound-healing activity of the skin of the common grape (Vitis Vinifera) variant, Cabernet Sauvignon

Phytother Res. 2010 Aug;24(8):1151-7. doi: 10.1002/ptr.2999.


The common Grape L. (Vitaceae) is regarded as an important medicinal plant. European healers have suggested the use of grapevine sap, juice, and whole grape in the treatment of pain, allergic reactions, inflammation, and to promote wound healing. We evaluated grape-skin powder for its wound-healing activity using an excision wound model in rats. Animals were randomly divided into three groups of six (n = 6) each. The test group animals were treated topically with the grape-skin powder (100 mg/kg/day). The controls and standard group animals were treated with petroleum jelly and mupirocin ointment respectively. Healing was assessed by the rate of wound contraction, period of epithelialization, and hydroxyproline content. On day 13, treatment of the wounds with grape-skin powder enhanced significantly the rate of wound contraction (100 %). Treated animals showed significant decrease in the epithelialization period (p < 0.000) and increase in the hydroxyproline content (p < 0.05) when compared to control and the standard. Histological analysis was also consistent with the proposal that grape-skin powder exhibits significant wound-healing potential. Increased rate of wound contraction, hydroxyproline content, and decrease in epithelialization time in the treated animals support the use of grape-skin powder in the management of wound healing.

MeSH terms

  • Animals
  • Granulation Tissue / drug effects
  • Hydroxyproline / analysis
  • Male
  • Phytotherapy*
  • Powders / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Vitis / chemistry*
  • Wound Healing / drug effects*


  • Powders
  • Hydroxyproline