Phosphine-mediated stereoselective reductive cyclopropanation of alpha-substituted allenoates with aromatic aldehydes

Org Lett. 2010 Feb 5;12(3):544-7. doi: 10.1021/ol902747c.

Abstract

A novel phosphine-mediated reductive cyclopropanation between alpha-substituted allenoates 2 and aldehydes 1 is described. It represents a new member of the allene-based annulations, which provides facile and efficient access to highly functionalized cyclopropanes 3 from simple and readily available starting materials. It also unveils an unprecedented reactivity pattern of allenoates with aldehydes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Alkadienes / chemistry*
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Cyclization
  • Cyclopropanes / chemical synthesis*
  • Cyclopropanes / chemistry
  • Molecular Structure
  • Phosphines / chemistry*
  • Stereoisomerism

Substances

  • Aldehydes
  • Alkadienes
  • Cyclopropanes
  • Phosphines
  • phosphine