Mechanisms of chromosome behaviour during mitosis

Nat Rev Mol Cell Biol. 2010 Feb;11(2):91-102. doi: 10.1038/nrm2832. Epub 2010 Jan 13.


For over a century, scientists have strived to understand the mechanisms that govern the accurate segregation of chromosomes during mitosis. The most intriguing feature of this process, which is particularly prominent in higher eukaryotes, is the complex behaviour exhibited by the chromosomes. This behaviour is based on specific and highly regulated interactions between the chromosomes and spindle microtubules. Recent discoveries, enabled by high-resolution imaging combined with the various genetic, molecular, cell biological and chemical tools, support the idea that establishing and controlling the dynamic interaction between chromosomes and microtubules is a major factor in genomic fidelity.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Biology*
  • Chromosomes*
  • Humans
  • Microtubules / metabolism
  • Microtubules / ultrastructure
  • Mitosis*
  • Spindle Apparatus / metabolism
  • Spindle Apparatus / ultrastructure