Immunosuppression reactivates and disseminates latent murine cytomegalovirus

J Gen Virol. 1977 Nov;37(2):419-23. doi: 10.1099/0022-1317-37-2-419.

Abstract

When searched for by standard virological methods, murine cytomegalovirus (MCMV) becomes undetectable by 4 months after inoculation of mice. However, a 2-week regimen of immunosuppression with antilymphocyte serum and corticosteroid results in reactivation and dissemination of the virus in virtually all animals. This system should be useful in defining the pathogenesis of generalized cytomegalic disease resulting from reactivation of latent virus in immunocompromised individuals.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antilymphocyte Serum / pharmacology
  • Cortisone / pharmacology
  • Cytomegalovirus / growth & development*
  • Cytomegalovirus / immunology
  • Cytomegalovirus / isolation & purification
  • Cytomegalovirus Infections / immunology
  • Cytomegalovirus Infections / microbiology*
  • Disease Models, Animal
  • Immunosuppression*
  • Mice
  • Organ Specificity
  • Salivary Glands / microbiology
  • Spleen / microbiology
  • Virus Replication / drug effects

Substances

  • Antilymphocyte Serum
  • Cortisone