Effect of micronutrients on behavior and mood in adults With ADHD: evidence from an 8-week open label trial with natural extension

J Atten Disord. 2011 Jan;15(1):79-91. doi: 10.1177/1087054709356173. Epub 2010 Jan 13.


Objective: To investigate the effect of a 36-ingredient micronutrient formula consisting mainly of minerals and vitamins in the treatment of adults with both ADHD and severe mood dysregulation (SMD).

Method: 14 medication-free adults (9 men, 5 women; 18-55 years) with ADHD and SMD completed an 8-week open-label trial.

Results: A minority reported transitory mild side effects. Significant improvements were noted across informants (self, observer, clinician) on measures of inattention and hyperactivity/impulsivity, mood, quality of life, anxiety, and stress all with medium to very large effect sizes (all ps < .01); however, the mean of inattention remained in a clinical range whereas the means on measures of mood and hyperactivity/impulsivity were normalized. Follow-up data showed maintenance of changes or further improvement for those who stayed on the micronutrients.

Conclusions: Although this study, as an open trial, does not in itself prove efficacy, it provides preliminary evidence supporting the need for a randomized clinical trial of micronutrients as treatment for the more complex presentations of ADHD.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Affect*
  • Anxiety / diet therapy
  • Attention Deficit Disorder with Hyperactivity / diet therapy*
  • Female
  • Humans
  • Male
  • Micronutrients / therapeutic use*
  • Middle Aged
  • Quality of Life*
  • Stress, Psychological / diet therapy*
  • Treatment Outcome


  • Micronutrients