Role of Krüppel-like factor 4 in phenotypic switching and proliferation of vascular smooth muscle cells

IUBMB Life. 2010 Feb;62(2):132-9. doi: 10.1002/iub.298.

Abstract

Phenotypic switching and proliferation of vascular smooth muscle cells (VSMCs) are critical components in the development of many vascular proliferation diseases such as atherosclerosis and restenosis after percutaneous coronary interventions. Krüppel-like factor 4 (KLF4) has been shown to play a key role in VSMC proliferation and differentiation. The focus of this review is to provide an overview for understanding the physiological and pathobiological roles of KLF4 in phenotypic switching and proliferation of VSMCs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / drug effects
  • Cell Differentiation / physiology*
  • Cell Proliferation / drug effects
  • Humans
  • Kruppel-Like Factor 4
  • Kruppel-Like Transcription Factors / physiology*
  • Muscle, Smooth, Vascular / cytology
  • Phenotype

Substances

  • KLF4 protein, human
  • Kruppel-Like Factor 4
  • Kruppel-Like Transcription Factors