Basal-like breast carcinoma: a phenotypically distinct entity

Arch Pathol Lab Med. 2010 Jan;134(1):130-3. doi: 10.5858/134.1.130.

Abstract

Gene microarray profiling of human breast carcinomas has recently categorized invasive breast carcinomas into 5 distinct subtypes; luminal A, luminal B, normal breastlike, human epithelial growth factor receptor 2 (HER2) overexpressing, and basal-like. Basal-like breast carcinomas are characterized by high expression of basal cytokeratins; low or absent expression of estrogen receptor, progesterone receptor, and HER2/neu; and expression of epidermal growth factor receptor (EGFR) and/or c-kit, and they are frequently associated with breast cancer 1 (BRCA1) mutations and poor clinical outcome. Recent studies have begun to provide insights into the molecular genetics, biology, morphology, and clinical outcome of this subtype of breast carcinoma. We reviewed the literature related to basal-like breast carcinomas to better understand this clinically significant subtype of breast carcinoma.

Publication types

  • Review

MeSH terms

  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology*
  • Carcinoma, Basal Cell / diagnosis
  • Carcinoma, Basal Cell / genetics
  • Carcinoma, Basal Cell / pathology*
  • Female
  • Gene Expression Profiling
  • Humans
  • Immunophenotyping
  • Prognosis
  • Receptor, ErbB-2 / genetics

Substances

  • ERBB2 protein, human
  • Receptor, ErbB-2