Relationship of non-alcoholic fatty liver disease to colorectal adenomatous polyps

J Gastroenterol Hepatol. 2010 Mar;25(3):562-7. doi: 10.1111/j.1440-1746.2009.06117.x. Epub 2010 Jan 13.


Background and aims: Metabolic syndrome and insulin resistance are associated with a higher risk of colon cancer. Non-alcoholic fatty liver disease (NAFLD) is regarded as a manifestation of metabolic syndrome in the liver. This investigation was initiated to determine whether NAFLD has a relationship to colorectal adenomatous polyps.

Methods: We examined the 2917 participants who underwent a routine colonoscopy at Kangbuk Samsung Hospital in 2007. We divided the 2917 subjects into the adenomatous polyp group (n = 556) and the normal group (n = 2361). Anthropometric measurements, biochemical tests for liver and metabolic function, and abdominal ultrasonographs were assessed.

Results: The prevalence of NAFLD was 41.5% in the adenomatous polyp group and 30.2% in the control group. By multiple logistic regression analysis, NAFLD was found to be associated with an increased risk of colorectal adenomatous polyps (odds ratio, 1.28; 95% confidence interval, 1.03-1.60). An increased risk for NAFLD was more evident in patients with a greater number of adenomatous polyps.

Conclusion: NAFLD was associated with colorectal adenomatous polyps. Further studies are needed to confirm whether NAFLD is a predictor for the development of colorectal adenomatous polyps and cancer.

MeSH terms

  • Adenomatous Polyps / complications*
  • Adenomatous Polyps / diagnosis
  • Adenomatous Polyps / epidemiology
  • Adult
  • Body Mass Index
  • Case-Control Studies
  • Colonoscopy
  • Colorectal Neoplasms / complications*
  • Colorectal Neoplasms / diagnosis
  • Colorectal Neoplasms / epidemiology
  • Fatty Liver / complications*
  • Fatty Liver / diagnosis
  • Fatty Liver / epidemiology
  • Fatty Liver, Alcoholic / complications
  • Female
  • Humans
  • Male
  • Metabolic Syndrome / complications
  • Middle Aged
  • Prevalence
  • Republic of Korea / epidemiology
  • Risk Factors
  • Statistics, Nonparametric