Clinical implications of adiponectin and inflammatory biomarkers in type 2 diabetes mellitus

Dis Markers. 2009;27(6):269-78. doi: 10.3233/DMA-2009-0672.

Abstract

Objectives: To study the interrelationships of adiponectin, C-reactive protein (CRP) and fibrinogen with each other in T2DM patients with (T2DM-C) and without complications (T2DM-NC) among healthy individuals.

Design and methods: The study comprised of 120 T2DM-C, 59 T2DM-NC patients and 40 healthy volunteers. Biochemical markers were determined in the serum.

Results: Positivity rates of CRP and fibrinogen were significantly increased in T2DM-C as compared to T2DM-NC or controls, whereas adiponectin showed highest level in healthy individuals. Inflammatory biomarkers were inversely correlated with adiponectin (P< 0.01). Lipid profiles, kidney functions and BMI, showed positive significant correlation with CRP and fibrinogen but negative correlation with adiponectin. For better detection of T2DM, the combined sensitivity (98.9%) and specificity (92.5%) of fibrinogen and adiponectin was higher than the combined sensitivity and specificity of fibrinogen and CRP or adiponectin and CRP or than that of the biomarkers alone.

Conclusion: Elevated levels of CRP and fibrinogen and reduced level of adiponectin can be used for early diagnosis of T2DM and can predict diabetic complications.

MeSH terms

  • Adiponectin / biosynthesis
  • Adiponectin / blood*
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers / blood*
  • Body Mass Index
  • C-Reactive Protein / metabolism*
  • Cohort Studies
  • Diabetes Mellitus, Type 2 / complications
  • Diabetes Mellitus, Type 2 / diagnosis*
  • Diabetes Mellitus, Type 2 / metabolism*
  • Diabetes Mellitus, Type 2 / physiopathology
  • Female
  • Fibrinogen / metabolism*
  • Humans
  • Inflammation / blood
  • Kidney / physiopathology
  • Lasers, Gas
  • Lipids / blood
  • Male
  • Middle Aged
  • Risk Factors
  • Sensitivity and Specificity
  • Vascular Diseases / etiology
  • Vascular Diseases / metabolism

Substances

  • Adiponectin
  • Biomarkers
  • Lipids
  • Fibrinogen
  • C-Reactive Protein