The senescence-associated secretory phenotype: the dark side of tumor suppression

Annu Rev Pathol. 2010;5:99-118. doi: 10.1146/annurev-pathol-121808-102144.

Abstract

Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescence-associated secretory phenotype (SASP) that turns senescent fibroblasts into proinflammatory cells that have the ability to promote tumor progression.

Publication types

  • Review

MeSH terms

  • Cell Transformation, Neoplastic / pathology
  • Cellular Senescence* / physiology
  • Fibroblasts / pathology
  • Humans
  • Neoplasms / pathology*
  • Neoplasms / physiopathology
  • Phenotype*
  • Tumor Suppressor Proteins / physiology

Substances

  • Tumor Suppressor Proteins