Autophagy takes flight in Drosophila

FEBS Lett. 2010 Apr 2;584(7):1342-9. doi: 10.1016/j.febslet.2010.01.006. Epub 2010 Jan 13.

Abstract

Drosophila has been shown to be a powerful model to study autophagy, whose regulation involves a core machinery consisting of Atg proteins and upstream signaling regulators similar to those in yeast and mammals. The conserved role in degrading proteins and organelles gives autophagy an important function in coordinating several cellular processes as well as in a number of pathological conditions. This review summarizes key studies in Drosophila autophagy research and discusses potential questions that may lead to better understanding of the roles and regulation of autophagy in higher eukaryotes.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Autophagy*
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / cytology*
  • Drosophila melanogaster / enzymology
  • Nerve Degeneration / pathology
  • Oxidative Stress
  • Protein Kinases / metabolism*
  • TOR Serine-Threonine Kinases

Substances

  • Drosophila Proteins
  • Protein Kinases
  • target of rapamycin protein, Drosophila
  • TOR Serine-Threonine Kinases