Higher fibrinogen levels predict progression of coronary artery calcification in adults with type 1 diabetes

Atherosclerosis. 2010 Jun;210(2):671-3. doi: 10.1016/j.atherosclerosis.2009.12.034. Epub 2010 Jan 4.


Aim: To determine whether fibrinogen levels predict independently progression of coronary artery calcification (CAC) in adults with type 1 diabetes.

Methods: Data from a prospective cohort--the Coronary Artery Calcification in Type 1 Diabetes Study--were evaluated. Fibrinogen levels at baseline were separated into quartiles. CAC was measured twice and averaged at baseline and at follow-up 2.4+/-0.4 years later. CAC progressors were defined as participants whose square-root transformed CAC volume increased by >or=2.5 mm3 or development of clinical coronary artery disease during the follow-up period.

Results: Fibrinogen levels were higher in progressors than in non-progressors (276+/-61 mg/dl versus 259+/-61 mg/dl, p=0.0003). CAC progression, adjusted for known cardiovascular risk factors, increased in the highest quartile.

Conclusions: Higher fibrinogen levels predict CAC progression in type 1 diabetes subjects, independent of standard cardiovascular risk factors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Calcinosis / blood*
  • Calcinosis / pathology
  • Cohort Studies
  • Coronary Artery Disease / blood*
  • Coronary Artery Disease / pathology
  • Diabetes Complications / blood*
  • Diabetes Mellitus, Type 1 / blood*
  • Disease Progression
  • Female
  • Fibrinogen / biosynthesis*
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors


  • Fibrinogen