Responses to drug therapy in ulcerative colitis. Evaluation by rectal biopsy and histopathological changes

Am J Gastroenterol. 1975 Nov;64(5):365-70.


To evaluate responses to medical therapy in ulcerative colitis, rectal biopsies of patients with active untreated disease, individuals with positive and negative sigmoidoscopic findings treated with salicylazosulfapyridine, prednisone and 6-mercaptopurine, alone and in combinations and noncolitis controls were compared histologically. Predominant histological observations were analyzed statistically. There were fewer crypt abscesses but more mucosal edema after all forms of therapy. Quantitative histopathological analysis failed to demonstrate that the response to one drug was significantly different from another.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Biopsy
  • Clinical Trials as Topic
  • Colitis, Ulcerative / drug therapy*
  • Colitis, Ulcerative / pathology
  • Drug Evaluation
  • Drug Therapy, Combination
  • Humans
  • Intestinal Mucosa / pathology
  • Mercaptopurine / therapeutic use*
  • Prednisone / therapeutic use*
  • Rectum / pathology
  • Remission, Spontaneous
  • Sigmoidoscopy
  • Sulfasalazine / therapeutic use*


  • Sulfasalazine
  • Mercaptopurine
  • Prednisone