Mitochondrial potassium channels and reactive oxygen species

FEBS Lett. 2010 May 17;584(10):2043-8. doi: 10.1016/j.febslet.2010.01.013. Epub 2010 Jan 16.


Pretreatment of tissues with potassium channel openers (KCO's) has been observed to be cytoprotective in a broad variety of insults. This phenomenon has been proposed to be intimately linked to activation of mitochondrial potassium channels which apparently modulate the mitochondrial production of reactive oxygen species (ROS). This critical review summarizes literature findings about the mitochondrial production of ROS, the action of KCO's on mitochondrial ROS production and the putative link to the cytoprotective action of these drugs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Survival
  • Humans
  • Ion Channel Gating
  • Mitochondria / metabolism*
  • Potassium Channels / metabolism*
  • Reactive Oxygen Species / metabolism*


  • Potassium Channels
  • Reactive Oxygen Species