Contribution of hypoxia-measuring molecular imaging techniques to radiotherapy planning and treatment

Clin Transl Oncol. 2010 Jan;12(1):22-6. doi: 10.1007/s12094-010-0462-3.

Abstract

Hypoxia is related to poor prognosis because it is associated to chemo- and radioresistance. During recent years the evolution of imaging methods like PET/CT and MRI has meant the appearance of new perspectives with direct implications in radiation therapy. We discuss previous experiences in staging, planning and in the follow-up process with these techniques for measuring tumour hypoxia.

Publication types

  • Evaluation Study
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism
  • Fluorodeoxyglucose F18
  • Humans
  • Hypoxia / genetics
  • Hypoxia / metabolism*
  • Immunohistochemistry
  • Molecular Imaging / methods*
  • Neoplasms / diagnosis
  • Neoplasms / metabolism
  • Neoplasms / radiotherapy*
  • Neoplasms / therapy*
  • Positron-Emission Tomography / methods
  • Prognosis
  • Radiotherapy Planning, Computer-Assisted / methods*
  • Tomography, X-Ray Computed / methods

Substances

  • Biomarkers, Tumor
  • Fluorodeoxyglucose F18