Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice

Pharmacol Rep. 2009 Nov-Dec;61(6):1179-83. doi: 10.1016/s1734-1140(09)70181-1.

Abstract

PRE-084, a selective sigma receptor agonist, exhibited an antidepressant-like effect in the forced swim test (FST) in Albino Swiss and C57BL/6J mice. This effect was counteracted by BD 1047 (5 and 10 mg/kg) but not by SM-21 (3 and 10 mg/kg), which are sigma(1)- and sigma(2)-receptor antagonists, respectively. The results indicated that PRE-084 has an antidepressant-like effect in C57BL/6J and, to a lesser extent, in Albino Swiss mice. These results support the idea that sigma(1)-receptors, but not sigma(2)-receptors, contribute to the mechanism of antidepressant activity of sigma agonists in FST.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antidepressive Agents / pharmacology*
  • Butyrates / administration & dosage
  • Butyrates / pharmacology
  • Depression / drug therapy*
  • Depression / physiopathology
  • Disease Models, Animal
  • Ethylenediamines / administration & dosage
  • Ethylenediamines / pharmacology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Morpholines / pharmacology*
  • Receptors, sigma / agonists*
  • Receptors, sigma / drug effects
  • Receptors, sigma / metabolism
  • Sigma-1 Receptor
  • Species Specificity
  • Swimming
  • Tropanes / administration & dosage
  • Tropanes / pharmacology

Substances

  • Antidepressive Agents
  • Butyrates
  • Ethylenediamines
  • Morpholines
  • Receptors, sigma
  • Tropanes
  • sigma-2 receptor
  • 2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate
  • SM 21
  • N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin