Abstract
PRE-084, a selective sigma receptor agonist, exhibited an antidepressant-like effect in the forced swim test (FST) in Albino Swiss and C57BL/6J mice. This effect was counteracted by BD 1047 (5 and 10 mg/kg) but not by SM-21 (3 and 10 mg/kg), which are sigma(1)- and sigma(2)-receptor antagonists, respectively. The results indicated that PRE-084 has an antidepressant-like effect in C57BL/6J and, to a lesser extent, in Albino Swiss mice. These results support the idea that sigma(1)-receptors, but not sigma(2)-receptors, contribute to the mechanism of antidepressant activity of sigma agonists in FST.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antidepressive Agents / pharmacology*
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Butyrates / administration & dosage
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Butyrates / pharmacology
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Depression / drug therapy*
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Depression / physiopathology
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Disease Models, Animal
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Ethylenediamines / administration & dosage
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Ethylenediamines / pharmacology
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Male
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Mice
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Mice, Inbred C57BL
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Morpholines / pharmacology*
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Receptors, sigma / agonists*
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Receptors, sigma / drug effects
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Receptors, sigma / metabolism
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Sigma-1 Receptor
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Species Specificity
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Swimming
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Tropanes / administration & dosage
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Tropanes / pharmacology
Substances
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Antidepressive Agents
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Butyrates
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Ethylenediamines
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Morpholines
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Receptors, sigma
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Tropanes
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sigma-2 receptor
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2-(4-morpholino)ethyl-1-phenylcyclohexane-1-carboxylate
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SM 21
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N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin