Tipping the scale: muscle versus fat

Nat Cell Biol. 2010 Feb;12(2):102-4. doi: 10.1038/ncb0210-102. Epub 2010 Jan 17.


Adipocytes and scar tissue form during skeletal muscle degeneration. Two new studies reveal that adipocytes and fibroblasts in skeletal muscle derive from a population of bipotent progenitors that reside within muscle, but are not derived from the muscle lineage. These progenitor cells also have a surprising role in stimulating the restoration of muscle mass during regeneration.

Publication types

  • Comment

MeSH terms

  • Adipocytes / cytology*
  • Adipocytes / metabolism
  • Adipose Tissue / cytology
  • Adipose Tissue / metabolism
  • Animals
  • Cell Differentiation / physiology
  • Fibroblasts / cytology
  • Mice
  • Models, Biological
  • Muscle, Skeletal / cytology*
  • Satellite Cells, Skeletal Muscle / cytology
  • Stem Cells / cytology*
  • Stem Cells / metabolism