Oxidative stress and cognitive longevity

Nutrition. 2010 Jun;26(6):595-603. doi: 10.1016/j.nut.2009.09.014. Epub 2010 Jan 18.

Abstract

Objective: The potential relation between metabolic activity within the central nervous system and retention of cognitive functioning capacity was assessed.

Methods: A detailed literature review was conducted and summarized.

Results: A large body of scientific evidence describes the interactions among cognitive activity, oxidative stress, neurodegeneration, neuroprotection, cognitive aging, and retention of cognitive functioning ability.

Conclusion: Maintenance of redox balance within the central nervous system can forestall cognitive decline and promote cognitive longevity.

Publication types

  • Review

MeSH terms

  • Acetylcarnitine / metabolism
  • Acetylcarnitine / pharmacology
  • Aging / metabolism*
  • Animals
  • Central Nervous System / metabolism*
  • Cognition / physiology*
  • Cognition Disorders / prevention & control*
  • Humans
  • Longevity
  • Mitochondria / metabolism
  • Neurodegenerative Diseases / prevention & control*
  • Oxidative Stress*
  • Phosphatidylserines / administration & dosage
  • Phosphatidylserines / metabolism

Substances

  • Phosphatidylserines
  • Acetylcarnitine