TLR signalling regulated antigen presentation in dendritic cells

Curr Opin Immunol. 2010 Feb;22(1):124-30. doi: 10.1016/j.coi.2009.12.005. Epub 2010 Jan 18.


Recent evidence suggests that TLR signalling in dendritic cells (DCs) transiently enhances antigen endocytosis and autophagy, augments the assembly of key antigen transport and processing systems, qualitatively modulates protein translation and induces a temporary cessation of DC motility. These rapid changes require activation of the MAP kinases, PI3-kinase and downstream signalling pathways and are observed in both myeloid DC and, with variations on the theme, in plasmacytoid DC.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • Cell Movement
  • Dendritic Cells / cytology
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism*
  • Humans
  • Protein Transport
  • Signal Transduction*
  • Toll-Like Receptors / immunology*
  • Toll-Like Receptors / metabolism


  • Toll-Like Receptors