Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 38 (2 Suppl), S3-9

Thrombotic Risk Factors: Basic Pathophysiology

Affiliations
Review

Thrombotic Risk Factors: Basic Pathophysiology

Ida Martinelli et al. Crit Care Med.

Abstract

Although venous thrombosis has been traditionally associated with stasis and hypercoagulability, arterial thrombosis is mainly associated with heightened platelet reactivity and damage to the vessel wall. Accordingly, classic risk factors for venous and arterial thrombosis are usually considered distinct. Those for the former include cancer, surgery, pregnancy, and estrogens use, whereas risk factors of arterial thrombosis include smoking, hypertension, diabetes, the metabolic syndrome, and hyperlipidemia. However, a number of studies have recently challenged this dichotomy, and it is now recognized that venous and arterial thromboses share several risk factors, suggesting a closer link between the two clinical conditions. Typical examples of shared risk factors are age and the metabolic syndrome. This review addresses the mechanism whereby established risk factors increase the risk of venous or arterial thrombosis, or both.

Similar articles

See all similar articles

Cited by 26 PubMed Central articles

See all "Cited by" articles

Substances

LinkOut - more resources

Feedback