Burkholdines 1097 and 1229, potent antifungal peptides from Burkholderia ambifaria 2.2N

Kamilia A Tawfik; Peter Jeffs; Brian Bray; George Dubay; Joseph O Falkinham; Mostafa Mesbah; Diaa Youssef; Sherief Khalifa; Eric W Schmidt

doi:10.1021/ol9029269

Burkholdines 1097 and 1229, potent antifungal peptides from Burkholderia ambifaria 2.2N

Org Lett. 2010 Feb 19;12(4):664-6. doi: 10.1021/ol9029269.

Authors

Kamilia A Tawfik¹, Peter Jeffs, Brian Bray, George Dubay, Joseph O Falkinham, Mostafa Mesbah, Diaa Youssef, Sherief Khalifa, Eric W Schmidt

Affiliation

¹ Department of Pharmacognosy, Suez Canal University, Ismailia, Egypt 41522.

PMID: 20085289
DOI: 10.1021/ol9029269

Abstract

Potent antifungal cyclic lipopeptides, burkholdines (Bk), were isolated from a culture of Burkholderia ambifaria 2.2N. Bk-1229 (1) and Bk-1097 (2) are octapeptides comprised of nonproteinogenic amino acids, including beta-hydroxytyrosine, beta-hydroxyasparagine, and a new fatty acyl amino acid. 1 and 2 are fungicidal against a panel of fungi with potencies 2-60-fold better than amphotericin B control.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Alternaria / drug effects
Antifungal Agents / chemistry
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology*
Ascomycota / drug effects
Botrytis / drug effects
Burkholderia / chemistry*
Lipopeptides / chemistry
Lipopeptides / isolation & purification*
Lipopeptides / pharmacology*
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Phytophthora infestans / drug effects

Substances

Antifungal Agents
Lipopeptides
burkholdine