Extremely low-frequency electromagnetic fields differentially regulate estrogen receptor-alpha and -beta expression in the rat olfactory bulb

Neurosci Lett. 2010 Mar 3;471(2):109-13. doi: 10.1016/j.neulet.2010.01.021. Epub 2010 Jan 18.


Recently, the effects of extremely low-frequency electromagnetic fields (ELF EMF) on biological systems have been extensively investigated. In this report, the influence of ELF EMF on olfactory bulb (OB) estrogen receptor-alpha (ER alpha) mRNA and -beta (ER beta) mRNA expression was studied by RT-PCR in adult female and male rats. Results reveal for the first time that ELF EMF exerted a biphasic effect on female OB ER beta mRNA gene expression, which increased during diestrous and decreased during estrous. We did not observe any influence of ELF EMF on female OB ER alpha mRNA expression. Our data demonstrate a fluctuating pattern of ER-alpha and -beta mRNA expression in the female OB throughout the phases of the estrous cycle in non-ELF EMF-exposed animals. Thus the highest ER alpha expression was observed in diestrous and the lowest in proestrous. The pattern of ER beta mRNA was less variable, the lowest expression was observed in diestrous. ER-alpha mRNA and -beta mRNA expression level in the male OB did not exhibit any variation either in ELF EMF-exposed or non-ELF EMF-exposed animals. In summary, ELF EMF modulate ER beta gene expression in the OB of female adult rats but not in males.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Electromagnetic Fields*
  • Estrogen Receptor alpha / biosynthesis*
  • Estrogen Receptor beta / biosynthesis*
  • Estrous Cycle
  • Female
  • Male
  • Memory / radiation effects*
  • Olfactory Bulb / metabolism*
  • Rats
  • Rats, Wistar
  • Recognition, Psychology / radiation effects*
  • Sex Factors
  • Social Behavior*


  • Estrogen Receptor alpha
  • Estrogen Receptor beta