TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion

Br J Cancer. 2010 Feb 16;102(4):639-44. doi: 10.1038/sj.bjc.6605530. Epub 2010 Jan 19.


Tumour necrosis factor-alpha (TNF-alpha) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-alpha in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-alpha as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-alpha and the nuclear factor-kappaB pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement / genetics*
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / pathology
  • Humans
  • Models, Biological
  • NF-kappa B / genetics
  • NF-kappa B / physiology*
  • Neoplasm Invasiveness
  • Neoplasms / genetics
  • Neoplasms / pathology*
  • Snail Family Transcription Factors
  • Transcription Factors / genetics
  • Transcription Factors / physiology*
  • Tumor Necrosis Factor-alpha / genetics
  • Tumor Necrosis Factor-alpha / physiology*


  • NF-kappa B
  • Snail Family Transcription Factors
  • Transcription Factors
  • Tumor Necrosis Factor-alpha