Abnormal neural oscillations and synchrony in schizophrenia

Nat Rev Neurosci. 2010 Feb;11(2):100-13. doi: 10.1038/nrn2774.


Converging evidence from electrophysiological, physiological and anatomical studies suggests that abnormalities in the synchronized oscillatory activity of neurons may have a central role in the pathophysiology of schizophrenia. Neural oscillations are a fundamental mechanism for the establishment of precise temporal relationships between neuronal responses that are in turn relevant for memory, perception and consciousness. In patients with schizophrenia, the synchronization of beta- and gamma-band activity is abnormal, suggesting a crucial role for dysfunctional oscillations in the generation of the cognitive deficits and other symptoms of the disorder. Dysfunctional oscillations may arise owing to anomalies in the brain's rhythm-generating networks of GABA (gamma-aminobutyric acid) interneurons and in cortico-cortical connections.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Clocks / physiology*
  • Cortical Synchronization* / psychology
  • Humans
  • Nerve Net / physiology
  • Neurons / physiology*
  • Schizophrenia / physiopathology*