Cell type-specific regulation of IL-10 expression in inflammation and disease

Immunol Res. 2010 Jul;47(1-3):185-206. doi: 10.1007/s12026-009-8150-5.


IL-10 plays an essential part in controlling inflammation and instructing adaptive immune responses. Consequently, dysregulation of IL-10 is linked with susceptibility to numerous infectious and autoimmune diseases in mouse models and in humans. It has become increasingly clear that appropriate temporal/spatial expression of IL-10 may be the key to how IL-10 contributes to the delicate balance between inflammation and immunoregulation. The mechanisms that govern the cell type- and receptor-specific induction of IL-10, however, remain unclear. This is due largely to the wide distribution of cellular sources that express IL-10 under diverse stimulation conditions and in a variety of tissue compartments. Further complicating the issue is the fact that human IL-10 expression patterns appear to be under genetic influence resulting in differential expression and disease susceptibility. In this review, we discuss the cellular sources of IL-10, their link to disease phenotypes and the molecular mechanisms implicated in IL-10 regulation.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology*
  • Dendritic Cells / immunology
  • Dendritic Cells / metabolism
  • Gene Expression Regulation / immunology*
  • Humans
  • Immunity, Cellular*
  • Infections / immunology*
  • Inflammation / immunology*
  • Interleukin-10 / genetics
  • Interleukin-10 / metabolism*
  • Macrophages / immunology
  • Macrophages / metabolism
  • Mice
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism


  • Interleukin-10