[Prospects of antisense therapy technologies]

Mol Biol (Mosk). Nov-Dec 2009;43(6):984-98.
[Article in Russian]

Abstract

Up-to now three variants of antisense technologies are known, namely antisense oligonucleotides, RNA interference, and ribozymes. In spite of different mechanisms of action, all of them are united by the common principle: an antisense preparation works after binding with RNA-target by forming a duplex. Today all three variants are intensively used in vivo. Present posture of affairs in use of antisense technologies for treating various diseases is considered in the review.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Genetic Therapy / methods*
  • Humans
  • Oligodeoxyribonucleotides, Antisense / genetics
  • Oligodeoxyribonucleotides, Antisense / metabolism
  • Oligodeoxyribonucleotides, Antisense / therapeutic use*
  • RNA / genetics
  • RNA / metabolism
  • RNA Interference*
  • RNA, Catalytic / genetics
  • RNA, Catalytic / metabolism
  • RNA, Catalytic / therapeutic use

Substances

  • Oligodeoxyribonucleotides, Antisense
  • RNA, Catalytic
  • RNA