[Chemotherapeutic wafers in treatment of malignant cerebral glioma. Assessment of a Cochrane review]

Ugeskr Laeger. 2010 Jan 18;172(3):214-7.
[Article in Danish]


The present Cochrane review deals with implantation of chemotherapeutic wafers in the surgical cavity after resection of a malignant glioma. The authors found two controlled, randomised studies concerning this treatment modality after first-time surgical treatment and one study dealing with treatment of recurrent tumour. An effect was shown in the first with an increase in median survival of 2 months equivalent to the survival seen after standard (concomitant) treatment. No effect was shown in recurrent tumour.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Antineoplastic Agents, Alkylating / administration & dosage*
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / mortality
  • Brain Neoplasms / surgery
  • Carmustine / administration & dosage*
  • Drug Implants
  • Evidence-Based Medicine
  • Glioma / drug therapy*
  • Glioma / mortality
  • Glioma / surgery
  • Humans
  • Neoplasm Recurrence, Local / drug therapy
  • Prognosis
  • Survival Rate
  • Treatment Outcome


  • Antineoplastic Agents, Alkylating
  • Drug Implants
  • Carmustine