Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators

Curr Opin Genet Dev. 2010 Feb;20(1):41-50. doi: 10.1016/j.gde.2009.12.001. Epub 2010 Jan 21.

Abstract

In this review we discuss both gene expression and protein localization changes of polarity proteins in carcinoma. We highlight the importance of protein mislocalization and its possible role in cancer. We also discuss the emerging role of polarity proteins as regulators of proliferation, apoptosis, tissue polarity, epithelial-mesenchymal transition, in addition to their known role in cell junction biogenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Apoptosis
  • Carcinoma / genetics*
  • Carcinoma / metabolism*
  • Cell Cycle Proteins / metabolism
  • Cell Movement
  • Cell Polarity / genetics*
  • Cell Proliferation
  • Eye Proteins / metabolism
  • Gene Expression
  • Humans
  • Membrane Proteins / genetics*
  • Membrane Proteins / metabolism*
  • Neoplasms / genetics*
  • Neoplasms / metabolism*
  • Nerve Tissue Proteins / metabolism
  • Nucleoside-Phosphate Kinase / metabolism

Substances

  • Adaptor Proteins, Signal Transducing
  • CRB1 protein, human
  • Cell Cycle Proteins
  • Eye Proteins
  • Membrane Proteins
  • Nerve Tissue Proteins
  • PARD3 protein, human
  • Nucleoside-Phosphate Kinase
  • MPP5 protein, human