Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene
- PMID: 20093034
- DOI: 10.1016/j.bmc.2009.12.070
Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene
Abstract
Two novel ergosterol derivatives, ganodermasides A and B, hydroxylated at C-15 were isolated from the methanol extract of spores of a medicinal mushroom, Ganoderma lucidum, showed to extend the replicative life span of Saccharomyces cerevisiae, a yeast of K6001 strain. The stereostructures of ganodermasides A and B were determined based on the spectroscopic analysis and comparison of spectroscopic data. These new sterols have a 4, 6, 8(14), 22-tetraene-3-one unit with a unique hydroxylation at C-15. The anti-aging activity of these compounds on yeast is comparable to a well-known substance, resveratrol. Based on results of the investigation of the mechanism of biological activity, ganodermasides A and B regulated UTH1 expression in order to extend the replicative life span of yeast.
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Similar articles
-
Ganodermasides C and D, two new anti-aging ergosterols from spores of the medicinal mushroom Ganoderma lucidum.Biosci Biotechnol Biochem. 2011;75(4):800-3. doi: 10.1271/bbb.100918. Epub 2011 Apr 22. Biosci Biotechnol Biochem. 2011. PMID: 21512225
-
Distribution of free and esterified ergosterols in the medicinal fungus Ganoderma lucidum.Appl Microbiol Biotechnol. 2007 Nov;77(1):159-65. doi: 10.1007/s00253-007-1147-x. Epub 2007 Aug 22. Appl Microbiol Biotechnol. 2007. PMID: 17712553
-
Anti-aging effects of hesperidin on Saccharomyces cerevisiae via inhibition of reactive oxygen species and UTH1 gene expression.Biosci Biotechnol Biochem. 2012;76(4):640-5. doi: 10.1271/bbb.110535. Epub 2012 Apr 7. Biosci Biotechnol Biochem. 2012. PMID: 22484922
-
Uth1p: a yeast mitochondrial protein at the crossroads of stress, degradation and cell death.FEMS Yeast Res. 2004 Nov;5(2):133-40. doi: 10.1016/j.femsyr.2004.05.001. FEMS Yeast Res. 2004. PMID: 15489196 Review.
-
Pharmacological Properties of Biocompounds from Spores of the Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes): A Review.Int J Med Mushrooms. 2016;18(9):757-767. doi: 10.1615/IntJMedMushrooms.v18.i9.10. Int J Med Mushrooms. 2016. PMID: 27910768 Review.
Cited by
-
Preparation and Characterization of Multilayer pH-Responsive Hydrogel Loaded Ganoderma lucidum Peptides.Foods. 2023 Mar 31;12(7):1481. doi: 10.3390/foods12071481. Foods. 2023. PMID: 37048304 Free PMC article.
-
Comparison of sterols and fatty acids in two species of Ganoderma.Chem Cent J. 2012 Jan 31;6(1):10. doi: 10.1186/1752-153X-6-10. Chem Cent J. 2012. PMID: 22293530 Free PMC article.
-
Neuroprotective Effects against Glutamate-Induced HT-22 Hippocampal Cell Damage and Caenorhabditis elegans Lifespan/Healthspan Enhancing Activity of Auricularia polytricha Mushroom Extracts.Pharmaceuticals (Basel). 2021 Sep 29;14(10):1001. doi: 10.3390/ph14101001. Pharmaceuticals (Basel). 2021. PMID: 34681226 Free PMC article.
-
Unlocking the Power: New Insights into the Anti-Aging Properties of Mushrooms.J Fungi (Basel). 2024 Mar 14;10(3):215. doi: 10.3390/jof10030215. J Fungi (Basel). 2024. PMID: 38535223 Free PMC article. Review.
-
The anti-fatigue and sleep-aiding effects vary significantly among different recipes containing Ganoderma lucidum extracts.Heliyon. 2024 May 8;10(10):e30907. doi: 10.1016/j.heliyon.2024.e30907. eCollection 2024 May 30. Heliyon. 2024. PMID: 38770283 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
