Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 327 (5964), 459-63

Requirement of Prorenin Receptor and Vacuolar H+-ATPase-mediated Acidification for Wnt Signaling


Requirement of Prorenin Receptor and Vacuolar H+-ATPase-mediated Acidification for Wnt Signaling

Cristina-Maria Cruciat et al. Science.


Wnt/beta-catenin signaling is important in stem cell biology, embryonic development, and disease, including cancer. However, the mechanism of Wnt signal transmission, notably how the receptors are activated, remains incompletely understood. We found that the prorenin receptor (PRR) is a component of the Wnt receptor complex. PRR functions in a renin-independent manner as an adaptor between Wnt receptors and the vacuolar H+-adenosine triphosphatase (V-ATPase) complex. Moreover, PRR and V-ATPase were required to mediate Wnt signaling during antero-posterior patterning of Xenopus early central nervous system development. The results reveal an unsuspected role for the prorenin receptor, V-ATPase activity, and acidification during Wnt/beta-catenin signaling.

Similar articles

  • Renin, (Pro)renin and Receptor: An Update
    G Nguyen. Clin Sci (Lond) 120 (5), 169-78. PMID 21087212. - Review
    PRR [(pro)renin receptor] was named after its biological characteristics, namely the binding of renin and of its inactive precursor prorenin, that triggers intracellular …
  • Frizzled-10 Promotes Sensory Neuron Development in Xenopus Embryos
    C Garcia-Morales et al. Dev Biol 335 (1), 143-55. PMID 19716814.
    Formation of the vertebrate nervous system requires coordinated cell-cell interactions, intracellular signalling events, gene transcription, and morphogenetic cell moveme …
  • Wnt/Frizzled Signaling Requires dPRR, the Drosophila Homolog of the Prorenin Receptor
    T Buechling et al. Curr Biol 20 (14), 1263-8. PMID 20579883.
    Wnt/Wg signaling pathways are of key importance during development and disease. Canonical and noncanonical Wnt/Frizzled (Fz) pathways share a limited number of signaling …
  • Wnt-frizzled Interactions in Xenopus
    H Steinbeisser et al. Methods Mol Biol 469, 451-63. PMID 19109725.
    The Wnt signaling cascades are regulatory modules which are involved in embryonic patterning, cell differentiation, morphogenesis, and diseases. The Wnt pathways are acti …
  • Prorenin Receptor Regulates More Than the Renin-Angiotensin System
    DN Müller et al. Ann Med 44 Suppl 1, S43-8. PMID 22713148. - Review
    The (pro)renin receptor (PRR) was initially believed to be a contributor to the pathogenesis of cardiovascular diseases via the amplification of renin- or prorenin-induce …
See all similar articles

Cited by 193 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms