Epstein-Barr virus-associated uterine leiomyosarcoma in an adult lung transplant patient

Obstet Gynecol. 2010 Feb;115(2 Pt 2):434-436. doi: 10.1097/AOG.0b013e3181c51ed0.


Background: Multiple viruses have been associated with carcinogenesis in solid-organ transplant patients. Although Epstein-Barr virus (EBV) has been associated with lymphomas in immunocompromised patients, an association with smooth muscle tumors recently has been described.

Case: An EBV immunoglobulin G-positive woman underwent bilateral lung transplant for sarcoidosis. She was placed on immunosuppression and prophylaxis for opportunistic infections. She presented 5 months later with an EBV-positive uterine leiomyosarcoma. Postoperative therapy included a decrease in immunosuppression and antiviral therapy. Recurrence was noted after 1 year; the patient developed sepsis while undergoing chemotherapy and declined further therapy.

Conclusion: Epstein-Barr virus-associated leiomyosarcoma can occur in the uterus in immunosuppressed patients.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Fatal Outcome
  • Female
  • Herpesvirus 4, Human / isolation & purification*
  • Humans
  • Immunocompromised Host*
  • Leiomyosarcoma / immunology
  • Leiomyosarcoma / pathology
  • Leiomyosarcoma / virology*
  • Lung Transplantation / immunology*
  • Neoplasm Recurrence, Local / virology*
  • Uterine Neoplasms / immunology
  • Uterine Neoplasms / pathology
  • Uterine Neoplasms / virology*