Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors

Nat Rev Cancer. 2010 Feb;10(2):138-46. doi: 10.1038/nrc2791.

Abstract

The precise mechanisms whereby anti-angiogenesis therapy blocks tumour growth or causes vascular toxicity are unknown. We propose that endothelial cells establish a vascular niche that promotes tumour growth and tissue repair not only by delivering nutrients and O2 but also through an 'angiocrine' mechanism by producing stem and progenitor cell-active trophogens. Identification of endothelial-derived instructive angiocrine factors will allow direct tumour targeting, while diminishing the unwanted side effects associated with the use of anti-angiogenic agents.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use*
  • Animals
  • Disease Progression
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / physiology
  • Growth Substances / metabolism*
  • Humans
  • Neoplasms / blood supply*
  • Neoplasms / drug therapy
  • Neoplastic Stem Cells / physiology
  • Neovascularization, Pathologic / drug therapy

Substances

  • Angiogenesis Inhibitors
  • Growth Substances

Grant support