[Protective properties of L-carnosine studied in vitro on a hemorrhagic stroke model]

Eksp Klin Farmakol. Nov-Dec 2009;72(6):46-8.
[Article in Russian]

Abstract

The protective properties of L-carnosine have been studied in vitro on a model of hemorrhagic stroke developed on survival olfactory cortex slices of hypertensive rats after long-term exposure to autoblood. The preliminary application of L-carnosine in a concentration of 5 mg/ml regenerates an activity of glutamatergic and GABAergic components of focal potentials inhibited by autoblood and prevents tissue swelling. L-carnosine protects the bioelectrical activity of nerve cells after their long-term exposure to autoblood and produces an antiedematic effect.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Carnosine / pharmacology*
  • Disease Models, Animal
  • Intracranial Hemorrhages / metabolism
  • Intracranial Hemorrhages / prevention & control*
  • Male
  • Rats
  • Rats, Inbred SHR
  • Stroke / metabolism
  • Stroke / prevention & control*

Substances

  • Carnosine