Pathogenic involvement of neuropeptides in anxiety and depression

Neuropeptides. 2010 Jun;44(3):215-24. doi: 10.1016/j.npep.2009.12.014. Epub 2010 Jan 21.


Anxiety and depression are highly prevalent disorders of mood posing significant challenges to individuals and society. Current evidence indicates no single neurobiological determinant underpins these conditions and an integrated approach in both research and treatment is expedient. Basic, behavioral, and clinical science indicates various stress-responsive neuropeptides in the neuroendocrine, autonomic, and behavioral pathophysiology of stress-related disorders including anxiety and depression. This review draws on recent research to capture the consensus and implications of neuropeptide research concerning the pathogenesis of anxiety and depression.

Publication types

  • Review

MeSH terms

  • Adaptation, Psychological
  • Animals
  • Anxiety Disorders / metabolism*
  • Depressive Disorder / metabolism*
  • Humans
  • Hypothalamo-Hypophyseal System / metabolism
  • Mice
  • Neuropeptides / metabolism*
  • Rats
  • Stress Disorders, Post-Traumatic / metabolism
  • Stress, Psychological / metabolism


  • Neuropeptides