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. 2010 Mar 30;399(1):129-133.
doi: 10.1016/j.virol.2009.12.023. Epub 2010 Jan 22.

Genomic Characterization of a Novel Human Papillomavirus (HPV-117) With a High Viral Load in a Persisting Wart

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Genomic Characterization of a Novel Human Papillomavirus (HPV-117) With a High Viral Load in a Persisting Wart

Anja Köhler et al. Virology. .

Abstract

Warts from immunosuppressed organ transplant recipients (OTR) persist over years and may progress into non-melanoma skin cancer. Human papillomaviruses (HPV) are considered the causal agents for the development of such warts. We isolated the novel type HPV-117 from a persisting wart by rolling circle amplification. One hundred eighteen warts from immunocompetent patients (IC) and 49 warts from OTR were analyzed by HPV-117 E6 type-specific PCR. As inferred from a phylogenetic analysis, the new type HPV-117 belonged to alpha-PV species 2, including the most similar types HPV-10 and HPV-94. The general prevalence of HPV-117 in warts was 2% in IC (2/118), and 12% in OTR (6/49). The high viral load in dysplastic cells of a Verruca vulgaris was shown by in situ hybridization. Our results suggest an active role of the novel type in the development of cutaneous warts of OTR.

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