Regulatory long non-coding RNAs and neuronal disorders

Physiol Behav. 2010 Jun 1;100(3):250-4. doi: 10.1016/j.physbeh.2010.01.015. Epub 2010 Jan 25.

Abstract

Increasing evidence suggests that GABA neuropathies play a major role in a variety of neuronal disorders. In addition, the role of non-coding RNAs in regulating a wide range of cellular processes is an intense area of investigation. This commentary discusses the intersection of these two fields, a corollary to the finding that adult hippocampal GABAergic interneuron development is controlled by an embryonic non-coding RNA during development.

Publication types

  • Research Support, American Recovery and Reinvestment Act
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Gene Expression Regulation, Developmental / genetics*
  • Hippocampus / growth & development
  • Hippocampus / metabolism
  • Humans
  • Interneurons / metabolism
  • Nervous System Diseases / genetics*
  • Nervous System Diseases / metabolism*
  • RNA, Untranslated / genetics
  • RNA, Untranslated / metabolism*
  • Regulatory Sequences, Ribonucleic Acid / genetics
  • Transcriptional Activation / genetics*
  • gamma-Aminobutyric Acid / genetics
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • RNA, Untranslated
  • Regulatory Sequences, Ribonucleic Acid
  • gamma-Aminobutyric Acid