Abstract
Increasing evidence suggests that GABA neuropathies play a major role in a variety of neuronal disorders. In addition, the role of non-coding RNAs in regulating a wide range of cellular processes is an intense area of investigation. This commentary discusses the intersection of these two fields, a corollary to the finding that adult hippocampal GABAergic interneuron development is controlled by an embryonic non-coding RNA during development.
Copyright 2010 Elsevier Inc. All rights reserved.
Publication types
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Research Support, American Recovery and Reinvestment Act
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Gene Expression Regulation, Developmental / genetics*
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Hippocampus / growth & development
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Hippocampus / metabolism
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Humans
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Interneurons / metabolism
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Nervous System Diseases / genetics*
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Nervous System Diseases / metabolism*
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RNA, Untranslated / genetics
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RNA, Untranslated / metabolism*
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Regulatory Sequences, Ribonucleic Acid / genetics
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Transcriptional Activation / genetics*
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gamma-Aminobutyric Acid / genetics
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gamma-Aminobutyric Acid / metabolism*
Substances
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RNA, Untranslated
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Regulatory Sequences, Ribonucleic Acid
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gamma-Aminobutyric Acid