Effect of different immunosuppressive schedules on recurrence-free survival after liver transplantation for hepatocellular carcinoma

Transplantation. 2010 Jan 27;89(2):227-31. doi: 10.1097/TP.0b013e3181c3c540.


Background: Tumor recurrence represents the main limitation of liver transplantation in patients with hepatocellular carcinoma (HCC) and can be favored by exposure to calcineurin inhibitors.

Methods: We investigated the effect of an immunosuppressant schedule that minimizes the exposure to calcineurin inhibitors on patients transplanted for HCC to ascertain whether this can reduce the tumor recurrence rate. For this purpose, we conducted a matched-cohort study: 31 patients with HCC transplanted between 2004 and 2007 who received sirolimus as part of their immunosuppression (group A) were compared with a control group of 31 patients (group B) transplanted in the same period who had the same prognostic factors but were given standard immunosuppression based on tacrolimus.

Results: Three-year recurrence-free survival was 86% in group A and 56% in group B (P=0.04). Although the prevalence of microvascular invasion G3-G4 grading and alpha-fetoprotein more than 200 ng/mL was identical in the two groups, exposure to tacrolimus was significantly higher in patients of group B (median, 8.54; range, 5.5-13.5) in comparison with those of group A (median, 4.6; range, 1.8-9.1) (P=0.0001).

Conclusions: By using sirolimus, exposure to calcineurin inhibitors can be minimized, reducing the risk of HCC recurrence.

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Aged
  • Carcinoma, Hepatocellular / etiology
  • Carcinoma, Hepatocellular / surgery*
  • Cohort Studies
  • Disease-Free Survival
  • Drug Administration Schedule
  • Female
  • Hepatitis B / complications
  • Hepatitis C / complications
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / therapeutic use*
  • Liver Neoplasms / etiology
  • Liver Neoplasms / surgery*
  • Liver Transplantation / adverse effects
  • Liver Transplantation / immunology*
  • Liver Transplantation / mortality
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / epidemiology*
  • Neoplasm Recurrence, Local / prevention & control
  • Risk Factors
  • Sirolimus / administration & dosage
  • Sirolimus / therapeutic use*
  • Survivors
  • Tacrolimus / administration & dosage
  • Tacrolimus / therapeutic use*
  • Young Adult


  • Adrenal Cortex Hormones
  • Immunosuppressive Agents
  • Sirolimus
  • Tacrolimus